ESR1 and breast carcinoma: Since proliferation of breast cancer cells is mediated by transmembrane growth factor receptors and intracellular hormone/steroid receptors including epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), HER3, KIT, estrogen receptor (ER), and progesterone receptor (PGR), we examined the effects of WT161 on receptor mRNA and protein expression.