Mutations in the High Iron Fe (HFE) genes (C282Y or H63D), less frequent mutations in the genes coding for hepcidin, ferroportin, transferrin receptor 2 or hemojuvelin (HFE2) are causes of hemochromatosis, which are characterized by the increased absorption of iron [27,28]. The gene discussed is HJV; the disease is hemochromatosis type 1.