SCD and pancreatic insulinoma: In fact, studies have shown that exposure of insulinoma cells to high glucose concentrations increases both c-Myc abundance and its association with its obligate heterodimer MAX to activate several glucose-responsive and de novo fatty acid synthesis genes, such as lactate dehydrogenase (LDH), L-pyruvate kinase (L-PK), pyruvate dehydrogenase (PDK-1), acetyl-CoA carboxylase (ACC), fatty acid synthetase (FASN) and stearoyl-CoA desaturase (SCD) [13].