Of these, immunofluorescent staining of GSC in GBM revealed the upregulation of Notch receptors 1 and 2 in a region with close approximation to VEC expressing Notch ligands JAGGED 1/2 (JAG1/2), and delta-like ligand 4 (DLI4), which have been shown to be vital for the self-renewal capacity of GSC [60]. The gene discussed is JAG1; the disease is glioblastoma.