KNG1 and central nervous system cancer: As a consequence of the significant role of BK in glioma perivascular satellitosis, a BK receptor inhibitor, Icatibant (Firazyr; Shire), has been tested in preclinical studies using glioma rat models and shown to be effective in impairing the migration of glioma cells through cerebral parenchyma and ultimately resulting in a smaller tumour mass [16].