Vascularity in gliomas was shown to be generated in both an oxygen-dependent and oxygen-independent manner via the master angiogenic regulators vascular endothelial growth factor (VEGF) and hypoxia induced factor-2α (HIF-2α) or through fibroblast growth factor 1 (FGF1) signalling pathways respectively [31,32,33]. The gene discussed is VEGFA; the disease is central nervous system cancer.