HLA-G and cytomegalovirus infection: Taken together, in the context of transplantation the immunosuppressive checkpoint molecule HLA-G plays an eminent role and may discrepantly affect transplant outcome: while on the one hand HLA-G is involved in tolerogenic responses and high levels of HLA-G are associated with better allograft acceptance [11], on the other hand HLA-G promotes viral immune evasion and as showed in our study HLA-G expression is significantly increased during CMV infection [9,10].