Up-regulation of SphK1 has been found in a wide array of human solid cancers and hematological malignancies [9]; the consequent elevated cellular levels of S1P promote cell survival, proliferation [10], and angiogenesis, indicating a major implication for SphK1 in the development and progression of cancer and chemo-resistance [11]. The gene discussed is SPHK1; the disease is hematologic disorder.