IGF1 and Cowden syndrome 1: Transcriptome analysis performed in mouse mutants carrying similar genetic defects as human patients suffering from progeroid CS or the related XPF-ERCC1 progeria (XFE), have highlighted that, similarly to normative aging mice [11,42,43], there is a dampening of the growth hormone/insulin-like growth factor 1 (GH/IGF1)-mediated somatotropic axis [44,45], a conserved signalling pathway regulating development, stress resistance and longevity [46,47,48].