Interestingly, bioinformatics predictions showed that some of the putative targets relate to several neurological pathways, including neurotrophin signaling pathway (ko04722), morphine addiction (ko05032), glutamatergic synapse (ko04724), GABAergic synapse (ko04727), axon guidance (ko04360), amphetamine addiction (ko05031) and nicotine addiction (ko0533). Here, BDNF is linked to nicotine dependence.