Among them, five pathways were highly related with cancer including transcriptional misregulation in cancer (ko05202), VEGF signaling pathway (ko04370), pathways in cancer (ko05200), pancreatic cancer (ko05212), non-small cell lung cancer (ko05223), while Type II diabetes mellitus (ko04930) and calcium signaling pathway (ko04020) were associated with cardiovascular and metabolism diseases. This evidence concerns the gene VEGFA and familial pancreatic carcinoma.