Among them, five pathways were highly related with cancer including transcriptional misregulation in cancer (ko05202), VEGF signaling pathway (ko04370), pathways in cancer (ko05200), pancreatic cancer (ko05212), non-small cell lung cancer (ko05223), while Type II diabetes mellitus (ko04930) and calcium signaling pathway (ko04020) were associated with cardiovascular and metabolism diseases. The gene discussed is VEGFA; the disease is metabolic disease.