In univariate analysis, p53 immunoreactivity showed a significant correlation with shorter PFS in colorectal patients (HR = 2.1, p = 0.03) and patients with colorectal tumors and distant metastases showing p53 immunoreactivity had a significantly shorter PFS and OS (HR = 2.6 and HR = 3.4, p = 0.03 and p = 0.02 respectively) compared to patients with non IR- tumors (Table 4). The gene discussed is TP53; the disease is colorectal neoplasm.