TP53 and colorectal neoplasm: In the group of patients presenting colorectal tumors with distant metastases, both PFS and OS were shorter for patients with tumors IR for p53, 3.3 and 8.2 months respectively, compared to non-IR tumors with median PFS of 5.9 months and OS 12.0 months (Fig 3D and 3E, p = 0.01 and p = 0.02 respectively).