We found that total plasma cholesterol level was associated with risk of a CKD event (IRR 1.48 per unit log total cholesterol, 95% CI 1.20, 1.83, p < 0.001), as were baseline CD4 count (IRR 0.90, 95% CI 0.86, 0.95, p < 0.001) and cumulative exposure to a PI (IRR 1.11 per year exposure, 95% CI 1.06, 1.15, p < 0.001) or to an N(t)RTI (IRR 1.05 per year exposure, 95% CI 1.03, 1.08, p < 0.001). This evidence concerns the gene CD4 and chronic kidney disease.