In line with these hypotheses, it was found that in kidney transplant recipients, the percentage of IL-7Rneg HCMV specific CD8+ T cells correlates with peak viral load in the acute phase of infection [17], while a higher concentration of inflammatory cytokines during T-cell priming promotes IL-7Rnegvs IL-7Rpos CD8+ T cells [27], and strong T-cell stimulation during priming determines a low frequency of IL-7Rpos CD4+ T cells [28]. The gene discussed is CD4; the disease is infection.