[9–12] CDH11 contributes to the mesenchymal phenotype and regulates cellular invasion.[9–12] CDH11 expression is increased during the differentiation of fibroblasts to myofibroblasts and may reinforce cell-to-cell adhesion and contractility.[7, 13] A role for CDH11 has also been proposed in SSc and idiopathic pulmonary fibrosis (IPF). This evidence concerns the gene CDH11 and systemic sclerosis.