CDH11 is increased in affected skin of SSc patients and the levels correlate with the extent of skin involvement and the expression of TGF-β related genes.[14] Furthermore, CDH11 regulates the development of skin and lung fibrosis induced by bleomycin.[2, 14] The bleomycin models are dependent on tissue injury and inflammation. The gene discussed is TGFB1; the disease is systemic sclerosis.