CDH11 and systemic sclerosis: For example, expression of CDH11 is increased in SSc skin and IPF lungs, where it is observed on fibroblasts, myofibroblasts, and macrophages.[2, 14] Furthermore, CDH11 deficient mice develop less dermal and lung fibrosis induced by bleomycin.[2, 14] Finally, monoclonal antibodies targeting CDH11 decrease dermal and lung fibrosis induced by bleomycin.