CDKN2A and mesothelioma: To explore the molecular events underlying progression of LNT- and LFA-induced inflammatory lesions to mesothelioma, was examined the status of the tumor suppressor gene Cdkn2a and its products p16 and p19, known to be disrupted in asbestos-induced mesothelioma in humans [31, 32] (Figures 4B–4E, S6, and S7).