Immunostaining of mesothelioma patient tissue demonstrated positive staining for the mesothelial marker HBME-1 and phosphorylated mTOR, 4EBP1, and Src in mesothelioma cells, as well as phospho-ERK1/2 in mesothelioma cells and fibroblasts, while phospho-STAT3 was predominant in lymphocytes and fibroblasts (Figure 1G). This evidence concerns the gene EIF4EBP1 and mesothelioma.