Consistent with loss of the CDKN2A-encoded proteins p16/p14 in human mesothelioma, loss of p16 and p19 protein expression was also evident in advanced LFA-induced lesions from animals that did not develop mesothelioma at the 1 year study end point (Figures 5B and 5C). The gene discussed is CDKN2A; the disease is mesothelioma.