Mechanistically, the silencing of NEK9 led to decreased phosphorylation of its downstream substrate CHK1 in WM1366 melanoma cells as well as the MIA PaCa‐2 KRAS‐mutant pancreatic cancer cell lines (Fig. 4C) (Kurioka et al., 2014). The gene discussed is CHEK1; the disease is familial pancreatic carcinoma.