ATM and cancer: In a similar manner, we also examined the capacity of the R101* and R837* mutant THRAP3 to promote the export of THRAP3-dependent transcripts, such as ATM, BRCA2, FANCD2, FANCL and RAD51. Importantly, both THRAP3 cancer associated mutants confered an mRNA export defect, similar to that observed in THRAP3-depleted cells, leading to defects in mRNA distribution and its accumulation within the nucleus (Figure 6C).