To functionally assess the effect of THRAP3 and BCLAF1 depletion on the FA/HR pathways, we examined the ability of THRAP3/BCLAF1 knockdown cells to form FANCD2 foci, a hallmark of a functional FA pathway, following MMC treatment (Supplementary Figure S7C and D). This evidence concerns the gene THRAP3 and Friedreich ataxia.