Nonetheless, and perhaps most strikingly, mRNAs encoding the vast majority of the proteins involved in the Fanconi Anaemia (FA) pathway and essential HR factors were downregulated in the cytoplasmic pool of THRAP3 and BCLAF1 depleted cells, potentially explaining the severe DNA repair defect observed in these cells. The gene discussed is BCLAF1; the disease is Fanconi anemia.