FASN and melanoma: For example, in melanoma cell lines, let7a inhibits some key anabolic enzymes such as G6PD, inosine monophosphate dehydrogenase (IMPDH2), Fatty Acid Synthase (FASN), stearoyl-CoA desaturase (SCD), and 4-phosphopantetheinyl transferase (AASDHPPT), leading to OxPhos and consequent oxidative stress induction [95].