In fact, melanoma cells express E-cadherin (CDH1) (which is fundamental for the contact with keratinocytes) [8], and as a consequence they can encounter an EMT-like process consisting of a decreased expression of CDH1 and increased expression of mesenchymal transcription factors like ZEB1, SNAIL1, or TWIST1 [5,7,9,10]. This evidence concerns the gene SNAI1 and melanoma.