CSF1-ETS2 axis mediates tumor-promoting M2 reprogramming of macrophages and it was demonstrated that miR-29a and miR21 target anti-angiogenic modulators and genes involved in M1 polarization (PDCD4, SPRY1, TIMP3 by miR-21 and miR-29a targets COL4A2, SPARC and TIMP3) influencing melanoma tumors growth and metastasis. This evidence concerns the gene TIMP3 and neoplasm.