A lack of mural cells, a poorly formed BM and a discontinuous endothelium, in which even tumor cells may be incorporated, render the tumor vasculature leaky and also promote metastasis, The tumor vasculature-surrounding ECM is anomalously rich in the oncofetal fibronectin ED-B splice variant, which is synthesized by neoplastic cells [140,141], and in tenascin-C and -W, which are synthesized by melanoma and glioblastoma cells and by CAFs of most carcinomas [101,142]. This evidence concerns the gene FN1 and melanoma.