The likewise laminin-binding galectin-3 [309] essentially promotes VM in melanoma by upregulating in melanoma cells the ectopic expression of genes that are otherwise typical for ECs, such as VE-cadherin, IL-8, fibronectin-1, endothelial differentiation sphingolipid G-protein receptor-1 (EDG-1), and MMP-2 [310]. This evidence concerns the gene MMP2 and melanoma.