Fruit peel polyphenolic extract from different sources (red grape, blackberry, black cherry, black currant, elderberry, blackthorn and plum) induced caspase-dependent cell death associated with an increase in oxidative stress, causing the release of pro- and anti-apoptotic mitochondrial proteins from the Bcl-2 family in breast cancer MCF-7 cells [130]. Here, BCL2 is linked to breast cancer.