AKT1 and breast cancer: Some polyphenols can induce tumor cell death through autophagy activation; for example, Solanum nigrum L. extract decreased p-AKT levels causing mTOR inactivation and triggering autophagy in AU565 human breast cancer cells [153], as well as blueberry polyphenols in MDA-MB231 cells [154] and grape skin extracts in a murine model of breast cancer [155].