AKT1 and breast cancer: HER2, p-Akt, p-MAPK and NF-κB oncoprotein levels decreased in a dose- and time-dependent way in BT-474, MCF- 7, MDA-MB-231 and SkBr3-hr (a herceptin-resistant strain from SkBr3 breast cancer cells) when treated with curcumin [217].