Conversely, genetic studies of syndromic forms of diabetes have resulted in the identification of an increasing number of genes responsible for monogenic diabetes, that frequently have a recessive inheritance, including WFS1 responsible for Wolfram syndrome [4], EIF2AK3 responsible for Wolcott–Rallison syndrome [5] and GLIS3 in neonatal diabetes and congenital hypothyroidism syndrome [6]. Here, WFS1 is linked to diabetes mellitus.