A stem cell-based etiology of the HGPS is also supported by the recent experimental work of Liu et al. [15], where a link between sirtuin 1 (SIRT1) longevity pathway and progeria is demonstrated and resveratrol (a potential SIRT1 activator) alleviates progeroid features in affected cells [15]. This evidence concerns the gene SIRT1 and Hutchinson-Gilford progeria syndrome.