Even though the etiology and pathogenesis of AD has not been fully elucidated [4,5,6], the hypotheses of AD pathogeneses include inflammation, oxidative stress, the accumulation of Aβ protein, lack of cholinergic neurotransmitter, the deposition of tau proteins and heavy metals, as well as the lack of neurotrophic factors, etc. Here, MAPT is linked to Alzheimer disease.