Considering the importance of DNA repair failures in cancerdevelopment, the aim of this work was to investigate the contribution of SNPs in keygenes XPD/Lys751Gln, APEX1/Asp148Glu andRAD51/G-135C in the susceptibility to PCa in a case-controlstudy in Rio de Janeiro, Brazil. The gene discussed is APEX1; the disease is posterior cortical atrophy.