BRCA2 and ovarian carcinoma: Although the functional consequences of this SNPremain to be clarified, a single nucleotide change in this CpG promoter island mayup-regulate gene expression, thus affecting RAD51 mRNA levels(Antoniou et al., 2007).This SNP has been linked to breast and ovarian cancer susceptibility due to thesupposed interaction of RAD51 with BRCA1 and BRCA2 proteins, with an especiallyhigher risk for carriers of BRCA2 mutations (Levy-Lahad et al., 2001).