Whilst high doses of exendin-4 (24 nmol kg−1day−1) for 4 weeks suppressed atherosclerosis in ApoE−/− mice fed a standard diet [30] monthly doses of 0.4 mg taspoglutide for 12 weeks did not reduce plaque area in hyperglycemic ApoE−/− mice fed a 45% fat diet [31]. Here, APOE is linked to atherosclerosis.