CNP and Alzheimer disease: We next found that the down-regulated ΔCnp and AD HIPP signatures intersected along with the mitochondrial gene set substantially more than expected due to chance (FE = 34, p = 2.1e-9; Fig. 7b), suggesting that the actual genes dysregulated in the mitochondria are similar between Cnp-KO mice and in the hippocampus of AD patients.