For this reason the detection of similar gene changes in brain tissue samples of Cnp-KO and Plp1-KO mice prior to the development of any axonal pathology [22, 24], allowed us to infer that the dysregulated expression of similar genes in murine samples and in human AD brains is suggestive of similar events occurring during the early part of the pathological cascade. This evidence concerns the gene PLP1 and Alzheimer disease.