Gain of chromosome 8q has moreover been described in other cancers: in oral squamous cell cancer gain of 8q could be found to be associated with lymph-node metastasis [38], in colorectal cancer this alteration occurred significantly more frequent in corresponding brain metastases [39] and in breast cancer gain of MYC defines the transition from pre-invasive ductal carcinoma to invasive ductal carcinoma [40]. Here, MYC is linked to metastatic malignant neoplasm in the lymph nodes.