Furthermore, we also explore the intratumor heterogeneity of TAGLN2 expression via IVY GAP Atlas (http://ivygap.org/), and the in situ hybridization (ISH) results indicated the positive staining of TAGLN2 both in tumor center and infiltrating zone in GBM tissue (Additional file 4: Fig. S4). This evidence concerns the gene TAGLN2 and neoplasm.