High TAGLN2 expression (> median value) had a significantly worse prognosis than those with low TAGLN2 expression in LGG (78.2 vs 114.0 months, P < 0.001) and GBM patients (12.5 vs 22.2 months, P < 0.05) in TCGA (n = 667) (Fig. 1e). Here, TAGLN2 is linked to glioblastoma.