INS and Insulin resistance: 2001). Because MCE treatment lowered the fasting serum insulin level, we speculate that the hypoglycaemic effect of MCE is to ameliorate insulin resistance rather than stimulate the pancreatic β-cell to secret insulin. Nowadays, homeostasis model assessment insulin resistance (HOMA-IR) has become the common index to evaluate the insulin sensibility, insulin resistance level, and the function of pancreatic β-cell (Fujino et al. 2013).