This result was consistent with the literature.25 This might be related to liver iron metabolism during anemia, because transferrin-transferrin receptor (TFR)-dependent endocytosis is one of the main molecular mechanisms for iron absorption during anemia in liver.26 Induction of TfR genes in this study might explain TFR-dependent regulation of iron uptake in HepG2 cells. The gene discussed is TF; the disease is anemia.