SPHK1 and multiple sclerosis: Safingol is a saturated analog of sphingosine and is a protein kinase C (PKC) inhibitor with SphK inhibitory properties.10 In combination with cisplatin, safingol has been successfully tested in phase I clinical trials of advanced solid tumors.6 Another compound, 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI-II), is widely used as a SphK1 and SphK2 inhibitor.11 The sphingosine analog FTY 720 is a drug that demonstrates great potential for kidney transplantation and the management of chronic autoimmune diseases such as multiple sclerosis.