BCL2 and cholangiocarcinoma: Binding of these Bcl-2 family proteins to Beclin 1 inhibits autophagy by altering the association of Beclin 1 and Class III phosphatidylinositol 3-kinase (PI3K) complexes.36 Ding et al.29 reported that ABC 294640-induced apoptosis in cholangiocarcinoma cells was enhanced when autophagy was inhibited by bafilomycin A1 or chloroquine.