Here, we investigated the effect of RES on ERK 1/2, p38-MAPK, Akt-1, and GSK-3β pathways which plays a critical role in cardiac hypertrophy and ventricular dilatation [29], myocyte survival, apoptosis, autophagy, and necrosis [29–31]. This evidence concerns the gene GSK3B and Ventriculomegaly.