PTGS1 and preeclampsia: As COX-1 expression is elevated in the placentas of women with pre-eclampsia 62, and COX inhibition improves fetal growth and attenuates late gestational hypertension in mice 63, we sought to examine whether SE175 exerts beneficial effects on human placental growth and function that are additional to those associated with the NO donor SNAP, which does not inhibit COX.