Decressac et al. administrated a single ICV injection of NPY to R6/2 mice (a transgenic model of Huntington's disease) and found that NPY improved motor function and extended survival time of the R6/2 mice through reduced body weight loss, meanwhile, NPY promoted cell proliferation and neuroblasts generation in the SVZ of R6/2 mice [91]. This evidence concerns the gene NPY and juvenile Huntington disease.