Long-term hyperinsulinemia can interfere with carbohydrate metabolism and weaken GA3PDH (glyceraldehyde-3-phosphate dehydrogenase) activity, which promotes the glycolytic metabolism of intermediate synthesis of ribose-5-phosphate (R-5-P), phosphoric acid (PPRP), and uric acid [40]. This evidence concerns the gene GAPDH and hyperinsulinism.