KLRK1 and hematopoietic and lymphoid system neoplasm: Similarly, the success of various inhibitors administered in mice that prevent the shedding of NKG2D ligands (NKG2D-L) or induce NKG2D-L expression on leukemic cells, and thereby enhancing cytotoxic killing, further demonstrates the significant role of NKG2D expression in immune surveillance of blood cancers (81, 82).