Low expression of CD1d correlate with poorer prognosis (16)Functional defects in NKT cells and CD1d downregulation induced by oncogene expression (17, 18)Tyrosine kinase inhibitor can restore iNKT cell functions (17)Activated iNKT cells is cytotoxic against CD1d+ tumor cells in vitro (19, 20). The gene discussed is CD1D; the disease is neoplasm.