Reduced frequency, function and expression of CD1d on tumors is associated with progression of disease (13, 24–28)Higher CD1d expression can also be associated with poor prognosis (27, 29)Higher presentation of tumor-associated lipids on CD1d can lead to impairment of CD3ζ signaling and poorer prognosis (29)Cultured iNKT-like/CIK cells are cytotoxic against tumor in vitro (30–33). This evidence concerns the gene CD1D and neoplasm.