In studies in CML patients, aberrant tyrosine kinase expression and dysfunctional Rho-associated protein kinase (ROCK) expression have been suggested to exert suppressive effects on iNKT cells by regulating the transcription factor PLZF, expression of CD95L and perforin (17) as well as altering CD1d expression on myeloid DCs (mDCs) (18). The gene discussed is CD1D; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.