Using blood culture-confirmed cases as the reference standard and applying a diagnostic threshold cut-off of 28.8EU (derived as described in Methods), anti-MP IgA ALS responses resulted in a test sensitivity of 85.7% (95% CI 69.7%−95.2%) and specificity of 51.4% (42.8–60.0%, Table 6). Here, CD79A is linked to amyotrophic lateral sclerosis.