The top 10 pathways included role of macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis, triggering receptor expression on myeloid cells-1 (TREM1) signaling, dendritic cell maturation, glucocorticoid receptor signaling, IL-6 signaling, high mobility group box chromosomal protein 1 (HMGB1) signaling, acute phase response signaling, IL-10 signaling, IL-15 signaling, and IL-12 signaling and production in macrophages. Here, IL6 is linked to rheumatoid arthritis.