However protein production in their study, e.g. albumin, is approximately 200-fold lower that obtained in our UCLBAL system in plasma of pigs with liver failure (Fig. 10 legend, derived from AUC data), and in culture medium production per cell is one tenth (Legallais et al. 49 <70 ng/million cells/h compared with UCL BAL >800 ng/106 cells/h;). Here, ALB is linked to Hepatic failure.