La knockdown resulted in significant reduction of both IFN-β and IFN-λ1 mRNA levels following SeV Cantell infection (Fig. 2a and b), whereas a reduction in only IFN-λ1 expression was observed in La-depleted cells following infection with rSeV/eGFP, albeit at the later time point of 48 hours post-infection (hpi) (Fig. 2e and f). The gene discussed is SSB; the disease is infection.