PIK3CA and cancer: For KEGG enrichment analysis (Fig. 7C), the results demonstrated that the interfered pathways of 81 genes co-existing in both backgrounds were mainly responsible for supporting cancer growth and invasion like HIF-1α signaling, focal adhesion signaling, PI3K-Akt signaling, Toll-like receptor signaling, TNF signaling, FoxO signaling, etc. We also performed a gene set (GSE5764 microarray set) enrichment analysis (GSEA) to reveal whether the 81 gene overlap were significantly enriched.