PFKFB3 and central nervous system cancer: Among the most strongly correlated genes were those involved in hypoxia and angiogenesis including VEGFA, VHL, ARNT, PGK130, ADM31, and EPO, as well as glycolytic response mediators HK1, PGK1, ALDOA, PFKFB3, PFKL and ENO1. Angiopoietin receptor32 and Notch signaling33 pathways were also significantly enriched in both glioma subtypes.