FGL2 and fulminant viral hepatitis: Moreover, in a viral fulminant hepatitis model, murine hepatitis virus strain-3 (MHV-3) infection induces a macrophage-dependent cytokine storm of IL-1, TNF, TGF-β, leukotriene B4, and pro-coagulant fibrinogen-like protein-2 (FGL2), which causes fibrin deposition in the liver and results in acute hepatic necrosis and lethality of susceptible mice7.