VSIG4 and infection: Interestingly, Vsig4-transgenetic mice had significant enhancing PDK2 expression while lessening PDH phosphorylation (p-PDH-E1αS300) in liver tissues at 72 h of MHV-3 infection (Fig. 8b), leading to lower levels of FGL2, TNF, IL-1β, and IL-6 deposition in liver tissues (Fig. 8b), together with reducing liver damage (Fig. 8c), along with a considerably improved survival rate (Fig. 8d).