We also identified down-regulated tumor proteins which have been associated with poor prognosis in breast cancers including monoacylglycerol lipase (MGL), AHNAK, MYOSIN-1C, guanine nucleotide binding protein GNAI1, serum deprivation response protein SDPR, EH domain containing EHD2 protein, Annexin A1, SPOCK2, Polymerase 1 and transcript release factor Catalase as well as a down-regulation of GAPDH an enzyme supporting the mostly down-regulated glycolysis pathway in the breast tumor, which has also apoptotic properties36. Here, SPOCK2 is linked to neoplasm.