Targeting cytochromes P450 was the best strategy for the therapeutic application in various disorders, including cancer, hypertension, various metabolic diseases, etc. Chun et al. [72] first reported 3,4,5,4′-TMS as a novel selective and strong inhibitor of human Cytochrome P450 1 (CYP1B1). This evidence concerns the gene CYP1B1 and cancer.