JUN and neoplasm: Although c-Jun is implicated in the promotion of a number of tumors, in other situations, it may have a role in the prevention of tumorigenesis by mechanisms that include activation of tumor suppressors such as P14ARF/p19ARFand Dmp1 (Eferl and Wagner, 2003; Ameyar-Zazoua et al., 2005; Shaulian, 2010).