An increase in Schwann cell number, a feature of many neuropathies including CMT1A (Robertson et al., 2002; Lupski and Chance, 2005), was also seen in c-Jun OE/OE nerves, the total number of Schwann cell nuclei per nerve profile being ∼6-fold that in WT (Fig. 5I). The gene discussed is PMP22; the disease is neuropathy.