SOX9 and Hepatic fibrosis: Thus, over 3 years liver fibrosis had progressed in 30 patients (26%), regressed in eight patients (7%), and remained unchanged in 77 (67%) allowing us to correlate SOX9 with severity (tissue remained from 152 biopsies for this purpose; Fig EV1) and disease progression (where tissue remained from 59 paired biopsies; Fig EV1).