SOX9 and Hepatic fibrosis: Our data on a cohort of patients with serial biopsies over time and variable fibrosis progression (Ghany et al, 2009; Liang & Ghany, 2013) provide three strands of evidence that SOX9's role in liver fibrosis in mouse seems likely in human: The profile of SOX9 detection following liver injury in patients was identical to that observed in mouse; the prevalence of de novo SOX9 expression in biopsies correlated precisely with fibrosis severity; and thirdly, the extent of SOX9 at early stages of disease predicted progression within 3 years.