KRAS and congenital rubella syndrome: These variables were included in a subsequent multivariate Cox regression analysis, which identified three independent prognostic factors for OS: Fong CRS > 2 (HR: 4.247; 95% CI: 1.758–8.260; p = 0.001), KRAS mutation (HR: 2.196; 95% CI: 1.372–3.515; p < 0.001) and poor response to preoperative chemotherapy (HR: 2.054; 95% CI: 1.025–4.119; p = 0.042) (Table 3).