CD274 and Merkel cell skin cancer: In particular, in a trial of avelumab (anti–PD-L1) performed in a stage IV metastatic MCC patient population similar to that in our study (ie, receiving second-line or later treatment), the ORR was 33% (95% CI, 23–44), with 74% of responses lasting ≥ 1 year based on Kaplan-Meier analysis, and a 1-year OS rate of 52% (95% CI, 41–62) [22, 32].