EDS also significantly affected most obesity indices (i.e., BMI, p < 0.001; NC, WC and WHR, p = 0.015, 0.002 and 0.004, respectively), contributed to glycometabolic disorders (as evidenced by higher levels of fasting plasma glucose and insulin, p = 0.001 and 0.003, respectively; and larger HOMA-IR, p < 0.001), and increased TG levels (p < 0.001) and metabolic score (p = 0.001). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.