APOE and obstructive sleep apnea syndrome: However, in the severe OSA group, significant differences were observed between the EDS and non-EDS groups: patients with EDS were more obese (as evidenced by a higher BMI and WHR, and larger NC, WC, and HC, p < 0.01), with higher systolic and diastolic blood pressure (p < 0.05), more severe insulin resistance (p < 0.01), more critical lipid abnormalities (as evidenced by higher levels of TC, TG, LDL, apoB, and apoE, p < 0.01), and worse sleep parameters (higher AHI, ODI, MAI, and lower LSpO2, p < 0.001; Supplementary Table 2).