The results showed that OSA significantly influenced the majority of metabolic indices (i.e., BMI, NC, WC, HC, WHR, systolic and diastolic blood pressure, fasting glucose level and insulin level, HOMA-IR, TC, TG, HDL, LDL, apoB, apoE, and metabolic score, p < 0.001; and apoA-I, p = 0.031), which resulted in more severe obesity, higher blood pressure, worse insulin resistance, and dyslipidemia. This evidence concerns the gene APOA1 and obesity due to melanocortin 4 receptor deficiency.