KLK3 and neoplasm: In univariate analysis the categorical PHI (cutoff 82) with an area under (AUC) the Receiver Operating Characteristic (ROC) curve of 66.4% was somewhat more accurate than stage (pT3 vs. pT2, AUC 66.3%), tumor volume (AUC 65.7%), pathological Gleason score ≥ 7 vs. ≤ 6 (ISUP grade ≥ 2 vs 1), (AUC 65.5%), surgical margin (resection) status (R1 vs. R0, AUC 64.6%) or PSA (AUC 60.1%) [24].