The downregulation of miR-143 in both colorectal cancer tissues and cell lines has been reported, and the abnormal expression of miR-143 can regulate cell proliferation, cell growth, clone formation, apoptosis, cell cycle, invasion and migration by targeting a number of genes including COX-2, MMP-13, GLI3, DNMT3A and KRAS [40–42]. Here, GLI3 is linked to colorectal cancer.